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Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Authors :
Gabriela Vasco
Mishell Achig
Belén Prado-Vivar
Maritza Páez
Franklin Espinosa
Evelyn Espinoza
Danny Quinancela
Paul Cardenas
Gabriel Trueba
Source :
Infection Prevention in Practice, Vol 6, Iss 1, Pp 100331- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Summary: Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

Details

Language :
English
ISSN :
25900889
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Infection Prevention in Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.5154d3662504812809ec2d06733f0db
Document Type :
article
Full Text :
https://doi.org/10.1016/j.infpip.2023.100331