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Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction

Authors :
Yusuke Yumita
Yuji Nagatomo
Makoto Takei
Mike Saji
Ayumi Goda
Takashi Kohno
Shintaro Nakano
Yosuke Nishihata
Yukinori Ikegami
Yasuyuki Shiraishi
Shun Kohsaka
Takeshi Adachi
Tsutomu Yoshikawa
Source :
Journal of Personalized Medicine, Vol 12, Iss 1, p 50 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (ΔHR) from −10 to ±0 was associated with a lower risk of primary endpoint and ΔHR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies.

Details

Language :
English
ISSN :
20754426
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Personalized Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.51329767224a4542a2d072d8d7bb0c2f
Document Type :
article
Full Text :
https://doi.org/10.3390/jpm12010050