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Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress
- Source :
- Arquivos Brasileiros de Cardiologia, Vol 114, Iss 1, Pp 100-105 (2019)
- Publication Year :
- 2019
- Publisher :
- Sociedade Brasileira de Cardiologia (SBC), 2019.
-
Abstract
- Abstract Background: The emergence of coronary heart disease is increased with menopause, physical inactivity and with dyslipidemia. Physical training is known to promote the improvement of cardiovascular functions. Objective: To investigate the effects of aerobic physical training on the left ventricle in ovariectomized LDL knockout mice. Methods: Thirty animals were divided into 6 groups (n = 5): Sedentary non-ovariectomized control; Sedentary ovariectomized control; Trained ovariectomized control; Sedentary non-ovariectomized LDL-knockout, sedentary ovariectomized LDL-knockout and trained ovariectomized LDL-knockout. We analyzed the average parameters of apparent density of collagen fibers types I and III, and metalloproteinase type 2 and type 9, were considered significant p < 0.05. Results: The results showed that the proposed exercise protocol altered the volume of type I collagen fibers, altered collagen remodeling parameters (MMP-2), and also reduced the 8-hydroxy-2’-deoxyguanosine (8OHdG) oxidative stress parameter. Conclusion: Moderate intensity aerobic training acts on collagen fiber volume, on collagen remodeling with the reduction of oxidative stress in the left ventricles of ovariectomized LDL-knockout mice.
Details
- Language :
- English, Portuguese
- ISSN :
- 16784170
- Volume :
- 114
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Arquivos Brasileiros de Cardiologia
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.50fe873c437431ebc2b5130b32fd99d
- Document Type :
- article
- Full Text :
- https://doi.org/10.5935/abc.20190223