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Clinical observations of the therapeutic effect of CLAG or FLAG bridging BuCy conditioning regimen in the treatment of childhood acute leukemia
- Source :
- Zhongguo shuxue zazhi, Vol 35, Iss 12, Pp 1230-1234 (2022)
- Publication Year :
- 2022
- Publisher :
- Institute of Blood Transfusion of Chinese Academy of Medical Sciences, 2022.
-
Abstract
- Objective To determine the therapeutic efficacy of cladribine combined with BuCy conditioning regimen for childhood acute leukemia, and compare it with fludarabine. Methods The clinical data of 70 children with acute leukemias who underwent all-HSCT from August 2018 to June 2020 were collected. The data of pretreatment-related toxicity, hematopoietic reconstitution, graft-versus-host disease, virus infection, relapsed and survival between CLAG and FLAG group were statistically analyzed. Results EBV infection in CLAG group was significantly more than that in FLAG group(P0.05). Multivariate analysis showed that there was no significant difference in the effect of conditioning regimen on relapsed and survival. Among other risk factors, types of diseases were significantly correlated with OS (P
Details
- Language :
- Chinese
- ISSN :
- 1004549X and 1004549x
- Volume :
- 35
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Zhongguo shuxue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.50bab2a4f8ed4fcdbdecbfe21f422bec
- Document Type :
- article
- Full Text :
- https://doi.org/10.13303/j.cjbt.issn.1004-549x.2022.12.010&lang=en