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Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects

Authors :
Mihai Popescu
Monica Scrieciu
Eugen Osiac
Marilena Bătăiosu
Diana Vlăduțu
Roxana Maria Pascu
Andreea Stănuși
Adina Dorina Glodeanu
Mihaela Ionescu
Veronica Mercuț
Source :
Diagnostics, Vol 12, Iss 3, p 636 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Developmental defects of enamel (DDEs) are deviations from the normal appearance in terms of the quantity and quality of tooth enamel. They may be genetic or acquired. The most important DDEs are hypomineralization and hypoplasia. The aim of this study was to produce “in vivo” DDE in Wistar rats by administering amoxicillin to pregnant females and to highlight these lesions after sacrifice of the pups by macroscopic and microscopic examination and optical coherence tomography (OCT). Amoxicillin (100 mg/kg) was administered to two pregnant Wistar female rats for the production of DDEs. When the pups were 2 months old, they were sacrificed, and their jaws were harvested together with their teeth. The jaws were examined macroscopically, microscopically, and by OCT. Following the macroscopic and microscopic examination, it was established that four pups had a total of 42 DDE lesions. At the OCT examination, the hypomineralization was characterized by an intense, inhomogeneous OCT signal, and the hypoplasia was characterized by the absence of the signal. Administration of amoxicillin to pregnant females of Wistar rats resulted in DDEs in their offspring. The OCT examination confirmed the presence of these lesions in the teeth of rat pups.

Details

Language :
English
ISSN :
20754418
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.50b1ec8a04e07a43fd149579ca790
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics12030636