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High-Grade Thalamic Glioma: Case Report with Literature Review

Authors :
Corneliu Toader
Mugurel Petrinel Radoi
Adrian Dumitru
Luca-Andrei Glavan
Razvan-Adrian Covache-Busuioc
Andrei Adrian Popa
Horia-Petre Costin
Antonio-Daniel Corlatescu
Alexandru Vladimir Ciurea
Source :
Medicina, Vol 60, Iss 10, p 1667 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

This case report delves into the case of a 56-year-old female patient presenting with progressive cephalalgia syndrome, nausea, vomiting, and gait disorders, diagnosed with a high-grade thalamic glioma. Glioma is the most common form of central nervous system (CNS) neoplasm that originates from glial cells. Gliomas are diffusely infiltrative tumors that affect the surrounding brain tissue. Glioblastoma is the most malignant type, while pilocytic astrocytomas are the least malignant brain tumors. In the past, these diffuse gliomas were classified into different subtypes and grades based on histopathologies such as a diffuse astrocytoma, oligodendrogliomas, or mixed gliomas/oligoastrocytomas. Currently, gliomas are classified based on molecular and genetic markers. After the gross total resection, a postoperative brain CT scan was conducted, which confirmed the quasi-complete resection of the tumor. The successful gross total resection of the tumor in this case, coupled with significant neurological improvement postoperatively, illustrates the potential benefits of aggressive surgical management for thalamic gliomas. This report advocates for further research to assess the efficacy of such interventions in malignant cases and to establish standardized treatment protocols, considering the heterogeneity in prognostic outcomes and the advancements in molecular diagnostics that offer deeper insights into glioma oncogenesis and progression.

Details

Language :
English
ISSN :
16489144 and 1010660X
Volume :
60
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Medicina
Publication Type :
Academic Journal
Accession number :
edsdoj.5060483747514ecb837d3adaf57a9bed
Document Type :
article
Full Text :
https://doi.org/10.3390/medicina60101667