Back to Search
Start Over
Cell type-specific induction of ferroptosis to boost antitumor immunity
- Source :
- OncoImmunology, Vol 12, Iss 1 (2023)
- Publication Year :
- 2023
- Publisher :
- Taylor & Francis Group, 2023.
-
Abstract
- ABSTRACTTraditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.
Details
- Language :
- English
- ISSN :
- 2162402X
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5039c7fc07124cccaa311199ef57718e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/2162402X.2023.2282252