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A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

Authors :
Shuo Xiao
Jonathan R. Coppeta
Hunter B. Rogers
Brett C. Isenberg
Jie Zhu
Susan A. Olalekan
Kelly E. McKinnon
Danijela Dokic
Alexandra S. Rashedi
Daniel J. Haisenleder
Saurabh S. Malpani
Chanel A. Arnold-Murray
Kuanwei Chen
Mingyang Jiang
Lu Bai
Catherine T. Nguyen
Jiyang Zhang
Monica M. Laronda
Thomas J. Hope
Kruti P. Maniar
Mary Ellen Pavone
Michael J. Avram
Elizabeth C. Sefton
Spiro Getsios
Joanna E. Burdette
J. Julie Kim
Jeffrey T. Borenstein
Teresa K. Woodruff
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

The female reproductive tract constitutes the ovary, fallopian tubes, uterus, and cervix, but it is challenging to engineer this systemin vitro. Here, the authors develop a microfluidic device (EVATAR) with reproductive tract and peripheral tissues to replicate hormone release of a 28-day menstrual cycle.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.502594c466a14109b2eb6d7e22593a42
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms14584