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A BCR-ABL1 cutoff of 1.5% at 3 months, determined by the GeneXpert system, predicts an optimal response in patients with chronic myeloid leukemia.

Authors :
Valentín García-Gutiérrez
María T Gómez-Casares
José M Puerta
Juan M Alonso-Domínguez
Santiago Osorio
Juan C Hernández-Boluda
Rosa Collado
María J Ramírez
Fátima Ibáñez
María L Martín
Juan D Rodríguez-Gambarte
Carolina Martínez-Laperche
Montse Gómez
Dolly V Fiallo
Sara Redondo
Alicia Rodríguez
Concepción Ruiz-Nuño
Juan L Steegmann
Antonio Jiménez-Velasco
Spanish Group of Chronic Myeloid Leukemia (GELMC)
Source :
PLoS ONE, Vol 12, Iss 3, p e0173532 (2017)
Publication Year :
2017
Publisher :
Public Library of Science (PLoS), 2017.

Abstract

In chronic myeloid leukemia (CML) patients, 3-month BCR-ABL1 levels have consistently been correlated with further outcomes. Monitoring molecular responses in CML using the GeneXpert (Cepheid) platform has shown an optimal correlation with standardized RQ-PCR (IS) when measuring BCR-ABL1 levels lower than 10%, as it is not accurate for values over 10%. The aim of the present study was to determine the predictive molecular value at three months on different outcome variables using the Xpert BCR-ABL1 MonitorTM assay (Xpert BCR-ABL1). We monitored 125 newly diagnosed consecutive CML patients in the chronic phase (CML-CP) using an automated method: Xpert BCR-ABL1. Only 5% of patients did not achieve an optimal response at 3 months, and the 10% BCR-ABL1 cutoff defined by RQ-PCR (IS) methods was unable to identify significant differences in the probabilities of achieving a complete cytogenetic response (CCyR) (50% vs. 87%, p = 0.1) or a major molecular response (MMR) (60% vs. 80%, p = 0.29) by 12 months. In contrast, a cutoff of 1.5% more accurately identified differences in the probabilities of achieving CCyR (98% vs. 54%, p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.500cdaa4961c4725b308dff06def0d31
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0173532