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HBsAg level and clinical course in patients with chronic hepatitis B treated with nucleoside analogue: five years of follow-up data
- Source :
- Clinical and Molecular Hepatology, Vol 19, Iss 4, Pp 409-416 (2013)
- Publication Year :
- 2013
- Publisher :
- Korean Association for the Study of the Liver, 2013.
-
Abstract
- Background/AimsQuantification of the hepatitis B surface antigen (HBsAg) is increasingly used to determine the treatment response in patients with chronic hepatitis B (CHB). However, there are limited data about the clinical implications of Quantification of HBsAg long-term nucleoside analogue treatment for CHB. We investigated the clinical correlation between HBsAg level and clinical course in patients with CHB who are treated long-term with nucleoside analogues.MethodsPatients with CHB who started lamivudine or entecavir monotherapy before June 2007 were enrolled. HBsAg was quantified at baseline, at 6 months, and at 1, 2, 3, 4, and 5 years of treatment. We compared data between the groups according to the presence or absence of a virological response (VR) and resistance.ResultsForty-eight patients were analyzed. There was no definite reduction in HBsAg level during the early period of treatment; differences in HBsAg levels between baseline and each time point were significant only at 5 years (P=0.028). In a subgroup analysis, this difference was significant only in non-resistant patients at 5 years (P=0.041).ConclusionsThere was no definite decrease in the HBsAg level during the early period of nucleoside analogue treatment, with long-term treatment being required to observe a significant reduction.
Details
- Language :
- English
- ISSN :
- 22872728 and 2287285X
- Volume :
- 19
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Molecular Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4fc152209c194c42b3183c47963b9e7b
- Document Type :
- article
- Full Text :
- https://doi.org/10.3350/cmh.2013.19.4.409