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Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts

Authors :
Rukhsana Gul
Meshail Okla
Amer Mahmood
Shahid Nawaz
Amina Fallata
Arwa Bazighifan
Musaad Alfayez
Assim A. Alfadda
Source :
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9316-9327 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Here, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing the expression of genes related to its biogenesis such as PGC-1α, NRF1, and TFAM. On the contrary, Neb but not Met-upregulated mitochondrial fusion-related genes such as OPA, and MFN2. In summary, our findings suggest that Neb and Met treatment significantly ameliorated the LPS-induced cytotoxicity and oxidative stress. Additionally, these findings suggest that Neb but not Met significantly down-regulates LPS-induced proinflammatory factors, probably by enhancing mitochondrial biogenesis and fusion.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
45
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.4fa02701ccbf42c6b3d35c5b3ab224aa
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb45110583