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Pancreatic cancer stemness: dynamic status in malignant progression

Authors :
Yutong Zhao
Cheng Qin
Bangbo Zhao
Yuanyang Wang
Zeru Li
Tianyu Li
Xiaoying Yang
Weibin Wang
Source :
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide. Increasing evidence suggests that the capacity for self-renewal, proliferation, and differentiation of pancreatic cancer stem cells (PCSCs) contribute to major challenges with current PC therapies, causing metastasis and therapeutic resistance, leading to recurrence and death in patients. The concept that PCSCs are characterized by their high plasticity and self-renewal capacities is central to this review. We focused specifically on the regulation of PCSCs, such as stemness-related signaling pathways, stimuli in tumor cells and the tumor microenvironment (TME), as well as the development of innovative stemness-targeted therapies. Understanding the biological behavior of PCSCs with plasticity and the molecular mechanisms regulating PC stemness will help to identify new treatment strategies to treat this horrible disease.

Details

Language :
English
ISSN :
17569966
Volume :
42
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Experimental & Clinical Cancer Research
Publication Type :
Academic Journal
Accession number :
edsdoj.4f9e2bae7b349158c69c65464f733d2
Document Type :
article
Full Text :
https://doi.org/10.1186/s13046-023-02693-2