Selective coupling reaction between 2,6-diiodoanisoles and terminal alkynes catalyzed by Pd(PPh3)2Cl2 and CuI

The cross-coupling reaction between aryl halides and terminal alkynes, catalyzed by palladium complexes and copper (I) salts, consists in an efficient synthetic tool for the formation of C-C bonds, resulting in disubstituted acetylenic compounds. Accordingly, in this work we present our preliminary results involving the selective cross-coupling reaction between 2,6-diiodoanisoles and terminal alkynes, catalyzed by Pd(PPh3)2Cl2 and CuI, in the formation of 2-iodo-alkynylanisoles (scheme 1).