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Immune Reconstitution of Patients Who Recovered From Steroid-Refractory Acute Graft-Versus-Host Disease After Basiliximab Treatment

Authors :
Dao-Xing Deng
Shuang Fan
Xiao-Hui Zhang
Lan-Ping Xu
Yu Wang
Chen-Hua Yan
Huan Chen
Yu-Hong Chen
Wei Han
Feng-Rong Wang
Jing-Zhi Wang
Xu-Ying Pei
Ying-Jun Chang
Kai-Yan Liu
Xiao-Jun Huang
Xiao-Dong Mo
Source :
Frontiers in Oncology, Vol 12 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

We aimed to identify the characteristics of immune reconstitution (IR) in patients who recovered from steroid-refractory acute graft-versus-host disease (SR-aGVHD) after basiliximab treatment. A total of 179, 124, 80, and 92 patients were included in the analysis for IR at 3, 6, 9, and 12 months, respectively, after haploidentical donor hematopoietic stem cell transplantation (HID HSCT). We observed that IR was fastest for monocytes and CD8+ T cells, followed by lymphocytes, CD3+ T cells, and CD19+ B cells and slowest for CD4+ T cells. Almost all immune cell subsets recovered comparably between patients receiving

Details

Language :
English
ISSN :
2234943X
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.4ef95849a95f46f1aa19b4f3226941fc
Document Type :
article
Full Text :
https://doi.org/10.3389/fonc.2022.916442