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The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
- Source :
- EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-28 (2021)
- Publication Year :
- 2021
- Publisher :
- SpringerOpen, 2021.
-
Abstract
- Abstract The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.
Details
- Language :
- English
- ISSN :
- 2365421X
- Volume :
- 6
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- EJNMMI Radiopharmacy and Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4e5f06acee8545c78faf7d07f37f6c28
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s41181-021-00141-0