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The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Authors :
Stephen J. Archibald
Louis Allott
Source :
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-28 (2021)
Publication Year :
2021
Publisher :
SpringerOpen, 2021.

Abstract

Abstract The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.

Details

Language :
English
ISSN :
2365421X
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
EJNMMI Radiopharmacy and Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.4e5f06acee8545c78faf7d07f37f6c28
Document Type :
article
Full Text :
https://doi.org/10.1186/s41181-021-00141-0