Back to Search
Start Over
Current understanding of genomic stability maintenancein pluripotent stem cells
- Source :
- Acta Biochimica et Biophysica Sinica, Vol 54, Pp 858-863 (2022)
- Publication Year :
- 2022
- Publisher :
- China Science Publishing & Media Ltd., 2022.
-
Abstract
- Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative medicine. Maintaining stable genome in culture is the first priority for stem cell application in clinics. In addition, genomic instability in PSCs can cause developmental failure or abnormalities. Understanding how PSCs maintain genome stability is of critical importance. Due to their fundamental role in organism development, PSCs must maintain superior stable genome than differentiated cells. However, the underlying mechanisms are far from clear. Very limited studies suggest that PSCs utilize specific strategies and regulators to robustly improve genome stability. In this review, we summarize the current understandings of the unique properties of genome stability maintenance in PSCs.
Details
- Language :
- English
- ISSN :
- 16729145
- Volume :
- 54
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Biochimica et Biophysica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4e3cda305fd24018bbf7b99eea0aed88
- Document Type :
- article
- Full Text :
- https://doi.org/10.3724/abbs.2022064