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Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L

Authors :
Qian-Qian Wei
Yanbing Hou
Yongping Chen
Ruwei Ou
Bei Cao
Lingyu Zhang
Tianmi Yang
Huifang Shang
Source :
Health and Quality of Life Outcomes, Vol 19, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background The study aimed to appraise the health-related quality of life (HRQoL) measured by the five-level EuroQol-5 dimensions (EQ-5D-5L) in amyotrophic lateral sclerosis (ALS), and to explore the associations between non-motor symptoms (mood changes, cognitive disturbances and sleep disturbances). Methods EQ-5D-5L descriptive scores were converted into a single aggregated “health utility” score. A calibrated visual analog scale (EQ-VAS) was used for self-rating of current health status. Multiple logistic regression analysis was used to explore the factors associated with HRQoL. Results Among the 547 enrolled ALS patients who were assessed using EQ-5D-5L, the highest frequency of reported problems was with usual activities (76.7%), followed by self-care (68.8%) and anxiety/depression (62.0%). The median health utility score was 0.78 and the median EQ-VAS score was 70. Clinical factors corresponding to differences in the EQ-5D-5L health utility score included age of onset, onset region, the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and King’s College stages. Patients with depression, anxiety, and poor sleep had lower health utility scores. Patients with excessive daytime sleepiness and rapid eye movement sleep behavior disorder had lower EQ-VAS scores. Multivariate logistic analysis indicated that ALSFRS-R scores, depression, and anxiety were associated with health utility scores. After adjusting other parameters, ALSFRS-R score, stages, and depression were significantly associated with EQ-VAS scores (P

Details

Language :
English
ISSN :
14777525
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Health and Quality of Life Outcomes
Publication Type :
Academic Journal
Accession number :
edsdoj.4e092c8417d5430399a0ee91fc47a69e
Document Type :
article
Full Text :
https://doi.org/10.1186/s12955-021-01822-9