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Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform

Authors :
Trong Nghia Nguyen
Thi Thuy Nguyen
Thi Ha Lien Nghiem
Duc Toan Nguyen
Thi Thu Ha Tran
Duong Vu
Thi Bich Ngoc Nguyen
Thi Minh Huyen Nguyen
Van Tien Nguyen
Minh Hue Nguyen
Source :
Molecules, Vol 26, Iss 13, p 3968 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Silica nanoparticles (SiO2 NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO2 NPs surfaces. The DOX·HCl loading onto and release from the SiO2 NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO2 NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO2 NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO2 NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO2 NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO2 systems are good candidates for drug delivery and clinical applications.

Details

Language :
English
ISSN :
14203049
Volume :
26
Issue :
13
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.4dee03c0c7a247ada1d9d8cdfcb6f6f1
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules26133968