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Proteins associated with incident metabolic syndrome in population-based cohorts
- Source :
- Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Abstract Background The metabolic syndrome (MetS) identifies persons with clustering of multiple cardiometabolic risk factors. The underlying pathology inducing this clustering is not fully known. We used a targeted proteomics assay to identify associations of circulating proteins with MetS and its components, cross-sectionally and longitudinally. Methods We explored and validated associations of 86 cardiovascular proteins, assessed using a proximity extension assay, with the MetS in two independent cohorts; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, n = 996) and Uppsala Longitudinal Study of Adult Men (ULSAM, n = 785). The analyses were adjusted for smoking, exercise habits, education, and energy and alcohol intake. Results Nine proteins were associated with all five components of the MetS in PIVUS using FDR
Details
- Language :
- English
- ISSN :
- 17585996
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Diabetology & Metabolic Syndrome
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4ddc44c466d842ab9f4e924599d5dbab
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13098-021-00752-2