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Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Authors :
Nikaïa Smith
Nicolas Pietrancosta
Sophia Davidson
Jacques Dutrieux
Lise Chauveau
Pasquale Cutolo
Michel Dy
Daniel Scott-Algara
Bénédicte Manoury
Onofrio Zirafi
Isabelle McCort-Tranchepain
Thierry Durroux
Françoise Bachelerie
Olivier Schwartz
Jan Münch
Andreas Wack
Sébastien Nisole
Jean-Philippe Herbeuval
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4dcfeb35184e41db9075187f20ab2655
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms14253