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Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Authors :
Burcak Yavuz
Esra Cansever Mutlu
Zubair Ahmed
Besim Ben-Nissan
Artemis Stamboulis
Source :
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5863 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

Details

Language :
English
ISSN :
25115863, 14220067, and 16616596
Volume :
25
Issue :
11
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.4d7b19ee48e45e3b647660ccac1482c
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25115863