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Blast crisis in chronic myeloid leukemia: An immunophenotypic analysis
- Source :
- International Journal of Science Annals, Vol 5, Iss 1-2, Pp 31-37 (2022)
- Publication Year :
- 2022
- Publisher :
- Kharkiv Regional Public Organization “Culture of Health”, 2022.
-
Abstract
- Background and Aim of Study: There are two different phases of untreated chronic myeloid leukemia – chronic phase, and blast crisis – according to the World Health Organization classification of Hematolymphoid tumors. The blast cells in the chronic myeloid leukemia blast crisis can express myeloid, lymphoid, bi-phenotypic, monocytic, megakaryocytic, and erythroid phenotypes. The immunophenotype of blast population determines how chronic myeloid leukemia – blast crisis patients respond to treatment, hence flowcytometric examination is required. The aim of the study: to assess immunophenotyping outcomes of flowcytometry performed on the chronic myeloid leukemia – blast crisis. Material and Methods: A five-year retrospective descriptive analysis was carried out in Pathology Department at King George’s Medical University Lucknow, India (2017-2021). The patient’s peripheral blood and bone marrow aspirate samples were analyzed. Clinical, hematological, and immunophenotypic data were retrieved. The flow cytometry samples were prepared using the standardized “lyse-stain-wash” method. Results: A total of 43 cases of chronic myeloid leukemia – blast crisis were retrieved from the departmental archive in 5 years. The mean age of study population was 39.62±14.86 years. There were 24 males and 19 females. 27 patients were diagnosed with myeloid blast crisis, 14 cases of B-lymphoid blast crisis and 2 cases of mixed phenotypic acute leukemia. Conclusions: Identification of the blast lineage of patients with chronic myeloid leukemia – blast crisis is crucial since the existence of atypical blast phenotypes influences the disease treatment and prognosis.
- Subjects :
- Education (General)
L7-991
Social sciences (General)
H1-99
Subjects
Details
- Language :
- English
- ISSN :
- 26172682
- Volume :
- 5
- Issue :
- 1-2
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Science Annals
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4d6f333252e141dda0d267bb8da51650
- Document Type :
- article
- Full Text :
- https://doi.org/10.26697/ijsa.2022.1-2.3