Back to Search
Start Over
HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors, by analysing methylation profiles, identify HOPX as a suppressor of metastasis in nasopharyngeal carcinoma: mechanistically HOPX inhibitsSNAILtranscription through deacetylation-mediated silencing.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4d4ea197e9e44305baa10870ac7c3417
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms14053