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Robust adaptive optics for localization microscopy deep in complex tissue

Authors :
Marijn E. Siemons
Naomi A. K. Hanemaaijer
Maarten H. P. Kole
Lukas C. Kapitein
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4cf76855b40cbb4c28ab779681f9f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23647-2