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Tropism and Infectivity of Pandemic Influenza A H1N1/09 Virus in the Human Placenta

Authors :
Yan-Na Xiao
Fei-Yuan Yu
Qian Xu
Jiang Gu
Source :
Viruses, Vol 14, Iss 12, p 2807 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Influenza virus infection in pregnant women may put the fetus at higher risk; however, to date, there has been no detailed research about the expression of influenza virus receptors in the human placenta. We employed the lectin staining technique, which is a classic influenza virus receptor research method for studying the distribution of viral receptors in the human placenta. In addition, we examined the susceptibility of the human placenta to H1N1/09, by detecting viral proteins and RNA at different time points post-infection. We found that the human placenta expressed both avian and human influenza A virus receptors (α-2, 3-linked sialic acid and α-2, 6-linked sialic acid). In addition, H1N1/09 did not only infect the human placenta, but also replicated and was released into the culture media. We concluded that the human placenta is susceptible to the 2009 influenza A virus (H1N1/09) infection, and that particular attention should be paid to shielding pregnant women from infection during influenza season.

Details

Language :
English
ISSN :
19994915
Volume :
14
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.4cafeb12dd814be898dfab964062d671
Document Type :
article
Full Text :
https://doi.org/10.3390/v14122807