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The effect of succinic acid on the metabolic profile in high‐fat diet‐induced obesity and insulin resistance
- Source :
- Physiological Reports, Vol 8, Iss 21, Pp n/a-n/a (2020)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Abstract Obesity, insulin resistance, and poor metabolic profile are hallmarks of a high‐fat diet (HFD), highlighting the need to understand underlying mechanisms. Therefore, we sought to determine the effect of succinic acid (SA) on metabolism in high‐fat diet (HFD)‐induced obesity. Animals were randomly assigned to either low‐fat diet (LFD) or a high‐fat diet (HFD). Mice consumed their respective diets for 4.5 months and then assigned to the following groups: (LFD)+vehicle, LFD + SA (0.75 mg/ml), HFD + vehicle, or HFD + SA. Body weight (BW), food, and water intake, were tracked weekly. After 6 weeks, insulin, glucose, and pyruvate tolerance tests were completed, and spontaneous physical activity was assessed. Epididymal white adipose tissue (EWAT) mass and in vitro measurements of oxidative skeletal muscle (soleus) respiration were obtained. Expectedly, the HFD increased BW and EWAT mass, and reduced glucose and insulin tolerance. SA significantly reduced EWAT mass, more so in HFD (p .05). A significant (p
- Subjects :
- metabolism
mitochondrial function
obesity
type 2 diabetes
Physiology
QP1-981
Subjects
Details
- Language :
- English
- ISSN :
- 2051817X
- Volume :
- 8
- Issue :
- 21
- Database :
- Directory of Open Access Journals
- Journal :
- Physiological Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4c691e191164d6984c747dd38193fe9
- Document Type :
- article
- Full Text :
- https://doi.org/10.14814/phy2.14630