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A cybergenetic framework for engineering intein-mediated integral feedback control systems

Authors :
Stanislav Anastassov
Maurice Filo
Ching-Hsiang Chang
Mustafa Khammash
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Homeostasis and robust perfect adaptation are remarkable features of living cells. Here, to synthetically achieve this, the authors present a theoretical and experimental framework using inteins to implement compact biomolecular integral feedback controllers.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 45874980
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4bc783ae2de24f45874980adc3a28e77
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36863-9