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Tribbles Gene Expression Profiles in Colorectal Cancer

Authors :
Mónica T. Fernandes
Victor Yassuda
José Bragança
Wolfgang Link
Bibiana I. Ferreira
Ana Luísa De Sousa-Coelho
Source :
Gastrointestinal Disorders, Vol 3, Iss 4, Pp 218-236 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death due to cancer in the world. Therefore, the identification of novel druggable targets is urgently needed. Tribbles proteins belong to a pseudokinase family, previously recognized in CRC as oncogenes and potential therapeutic targets. Here, we analyzed the expression of TRIB1, TRIB2, and TRIB3 simultaneously in 33 data sets from CRC based on available GEO profiles. We show that all three Tribbles genes are overrepresented in CRC cell lines and primary tumors, though depending on specific features of the CRC samples. Higher expression of TRIB2 in the tumor microenvironment and TRIB3 overexpression in an early stage of CRC development, unveil a potential and unexplored role for these proteins in the context of CRC. Differential Tribbles expression was also explored in diverse cellular experimental conditions where either genetic or pharmacological approaches were used, providing novel hints for future research. This comprehensive bioinformatic analysis provides new insights into Tribbles gene expression and transcript regulation in CRC.

Details

Language :
English
ISSN :
26245647
Volume :
3
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Gastrointestinal Disorders
Publication Type :
Academic Journal
Accession number :
edsdoj.4b7eddd73718442fb80be4be470c2766
Document Type :
article
Full Text :
https://doi.org/10.3390/gidisord3040021