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Biomarkers for Basal-like Breast Cancer
- Source :
- Cancers, Vol 2, Iss 2, Pp 1040-1065 (2010)
- Publication Year :
- 2010
- Publisher :
- MDPI AG, 2010.
-
Abstract
- Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 2
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4affc30a7d7d4acc848a55cd9e021119
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cancers2021040