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The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018

Authors :
Tao Li
Yixuan Xie
Liang Wang
Guimin Huang
Yijing Cheng
Dongqing Hou
Wenqian Liu
Tong Zhang
Junting Liu
Source :
Nutrients, Vol 14, Iss 7, p 1523 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

There are few studies on lead’s effect on bone mineral density (BMD) in childhood. In this study, we examined the association between lead exposure and BMD among 13,951 children and adolescents aged 8–19 years from NHANES 1999–2006 and 2011–2018. The whole blood lead levels (BLLs) were used as lead exposure biomarkers, and total BMD, subtotal BMD, lumbar spine BMD and limb BMD were used as outcome variables. The survey weighted multivariable generalized additive models (GAMs) with smoothing terms were used to explore the association between blood lead levels and BMDs, adjusted for age, sex, race/ethnicity, height, weight, family-income-to-poverty ratio and blood cadmium. Subgroup analyses stratified by sex and bony sites were further performed. We found an N-shaped curve association between BLLs and total BMD, subtotal BMD and limb BMD for males and females, whereas the association between BLLs and lumbar spine BMD was only significantly negative for females. The findings suggested that lead exposure had different effects on BMD of different bony sites (highly cortical or trabecular regions) in childhood and adolescence and had different effects on the same bone among different ages population and/or at different levels.

Details

Language :
English
ISSN :
20726643
Volume :
14
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.4ae4fb37766d4fc49b5833a80ef17af5
Document Type :
article
Full Text :
https://doi.org/10.3390/nu14071523