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L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans

L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans

Authors :
Liangwen Chen
Guijie Chen
Tingting Gai
Xiuhong Zhou
Jinchi Zhu
Ruiyi Wang
Xuemei Wang
Yujie Guo
Yun Wang
Zhongwen Xie
Source :
Molecules, Vol 29, Iss 11, p 2691 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effects, regulation of the immune response, relaxing neural tension, and reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also upregulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provides a theoretical basis for the possibility that tea drinking may prevent mitochondrial-related diseases.

Details

Language :
English
ISSN :
14203049
Volume :
29
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.4a3b04c10dad49c5b78b7ef2ade6c46e
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules29112691