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Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

Authors :
Adam B. Weiner
Thiago Vidotto
Yang Liu
Adrianna A. Mendes
Daniela C. Salles
Farzana A. Faisal
Sanjana Murali
Matthew McFarlane
Eddie L. Imada
Xin Zhao
Ziwen Li
Elai Davicioni
Luigi Marchionni
Arul M. Chinnaiyan
Stephen J. Freedland
Daniel E. Spratt
Jennifer D. Wu
Tamara L. Lotan
Edward M. Schaeffer
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

A recent report suggested Black men with prostate cancer were more responsive to immunotherapy. Here, the authors analysed prostate cancer gene expression profiles and show tumours from Black men and men with African ancestry have an increased proportion of plasma cells compared to those of White men and this correlates with improved outcome following treatment.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4a17424a6fc14795b82dff2e77510b55
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21245-w