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Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study

Authors :
Yasuhiro Matsuda
Bayarchimeg Altankhishig
Katsushi Okuyama
Hiroko Yamamoto
Katsuaki Naito
Mikako Hayashi
Hidehiko Sano
Sharanbir K. Sidhu
Takashi Saito
Source :
Journal of Functional Biomaterials, Vol 13, Iss 4, p 246 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Several desensitizers routinely used clinically for dentin hypersensitivity are expected to inhibit demineralization. This study aimed to evaluate the effectiveness of sealing materials in inhibiting demineralization and increasing fluorine (F) uptake by acid-treated root surfaces. Five noncarious extracted human teeth were used to produce specimens. Three different fluoride-containing materials, namely “MS Coat F” (MS), “MS Coat Hys Block Gel” (HS), and CTX2 Varnish (FV), were used herein. Each material was applied to the demineralized root surface. Single sections were obtained from each specimen. All surfaces of each specimen, except the polished surface, were covered with wax and immersed in an automatic pH cycling system for 2 weeks. Fluorine and calcium distributions in the carious lesions of each specimen were evaluated using proton-induced gamma emission (PIGE) and X-ray (PIXE) techniques, respectively. Dentin demineralization was analyzed using transverse microradiography (TMR) before and after pH cycling. µPIXE/PIGE analysis demonstrated that all sample groups showed increased fluoride uptake on the root surface. TMR analysis revealed that both HS and FV showed significantly lower integrated mineral loss values than the control group. All three samples demonstrated a tendency towards increased fluoride uptake from fluoride-containing hypersensitivity desensitizers and a demineralization inhibition effect on root dentin.

Details

Language :
English
ISSN :
20794983
Volume :
13
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Journal of Functional Biomaterials
Publication Type :
Academic Journal
Accession number :
edsdoj.4a071af28a96423aa9be0ae39727b613
Document Type :
article
Full Text :
https://doi.org/10.3390/jfb13040246