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ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes

Authors :
Qing Ma
Yini Xiao
Wenjun Xu
Menghan Wang
Sheng Li
Zhihao Yang
Minglu Xu
Tengjiao Zhang
Zhen-Ning Zhang
Rui Hu
Qiang Su
Fei Yuan
Tinghui Xiao
Xuan Wang
Qing He
Jiaxu Zhao
Zheng-jun Chen
Zhejin Sheng
Mengyao Chai
Hong Wang
Weiyang Shi
Qiaolin Deng
Xin Cheng
Weida Li
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Immature function and fragility hinder application of hESC-derived β cells (SC-β cell) for diabetes cell therapy. Here, the authors identify ZnT8 as a gene editing target to enhance the insulin secretion and cell survival under metabolic stress by abolishing zinc transport in SC-β cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.498f4e26b64740c4ac0e64e6b7a3344f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31829-9