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HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants

Authors :
Sebastian Fritzwanker
Lionel Moulédous
Catherine Mollereau
Carine Froment
Odile Burlet-Schiltz
Felix Effah
Alexis Bailey
Mariana Spetea
Rainer K. Reinscheid
Stefan Schulz
Andrea Kliewer
Source :
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Fritzwanker et al. develop a knock-in transgenic mouse line in which the hemagglutinin epitope tag sequence is fused with the amino-terminus of the µ-opioid receptor. Their model enables more efficient immunodetection of G protein-coupled receptors.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.495c33f2d6324ceca45d00dab8a2f7bb
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-021-02580-6