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Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

Authors :
Sapna Sharma
Thomas Vercruysse
Lorena Sanchez-Felipe
Winnie Kerstens
Madina Rasulova
Lindsey Bervoets
Carolien De Keyzer
Rana Abdelnabi
Caroline S. Foo
Viktor Lemmens
Dominique Van Looveren
Piet Maes
Guy Baele
Birgit Weynand
Philippe Lemey
Johan Neyts
Hendrik Jan Thibaut
Kai Dallmeier
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Currently licensed COVID-19 vaccines are based on antigen sequences of early SARS-CoV-2 isolates, despite the prevalence of variants of concerns escaping vaccine-mediated protection. Using their updated yellow fever 17D vectored candidate, here, authors assess neutralising antibody responses against variants of concern, and demonstrate protection and reduced transmission in a hamster model.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4924ff2c0d8d4311b6386793aa74eaa2
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34439-7