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Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs

Authors :
Aura Rocío Hernández
Ekaterina Bogdanova
Jesus E. Campos Pacheco
Vitaly Kocherbitov
Mikael Ekström
Georgia Pilkington
Sabrina Valetti
Source :
Drug Delivery, Vol 31, Iss 1 (2024)
Publication Year :
2024
Publisher :
Taylor & Francis Group, 2024.

Abstract

Pulmonary delivery and formulation of biologics are among the more complex and growing scientific topics in drug delivery. We herein developed a dry powder formulation using disordered mesoporous silica particles (MSP) as the sole excipient and lysozyme, the most abundant antimicrobial proteins in the airways, as model protein. The MSP had the optimal size for lung deposition (2.43 ± 0.13 µm). A maximum lysozyme loading capacity (0.35 mg/mg) was achieved in 150 mM PBS, which was seven times greater than that in water. After washing and freeze-drying, we obtained a dry powder consisting of spherical, non-aggregated particles, free from residual buffer, or unabsorbed lysozyme. The presence of lysozyme was confirmed by TGA and FT-IR, while N2 adsorption/desorption and SAXS analysis indicate that the protein is confined within the internal mesoporous structure. The dry powder exhibited excellent aerodynamic performance (fine particle fraction

Details

Language :
English
ISSN :
10717544 and 15210464
Volume :
31
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Drug Delivery
Publication Type :
Academic Journal
Accession number :
edsdoj.48fe2cead058404c9d35312453e9b037
Document Type :
article
Full Text :
https://doi.org/10.1080/10717544.2024.2381340