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Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells [version 1; referees: 3 approved]
- Source :
- F1000Research, Vol 4 (2015)
- Publication Year :
- 2015
- Publisher :
- F1000 Research Ltd, 2015.
-
Abstract
- Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.
Details
- Language :
- English
- ISSN :
- 20461402
- Volume :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- F1000Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.48fb732a8a4098aebd58a1272638e5
- Document Type :
- article
- Full Text :
- https://doi.org/10.12688/f1000research.7010.1