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Basic characterization and Alzheimer’s disease relieving property of a glucose riched polysaccharide from Cibotium barometz
- Source :
- Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104597- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- The water-soluble polysaccharides from plants have attracted ever-increasing attention in the field of food and drug due to their various activities and low toxicity. CBP50-1, as a purified fraction of polysaccharide from the rhizome of Cibotium barometz (CBP), mainly consisted of glucose (55.45%) and xylose (25.27%). CBP50-1 showed excellent antioxidant activity for scavenging 2,2‑Diphenyl‑1‑picryl‑hydrazy (DPPH) radical and hydroxyl radical, further inhibiting lipid peroxidation. CBP50-1 significantly improved the survival rate of Caenorhabditis elegans under thermal and oxidative stress. Furthermore, CBP50-1 reduced the paralysis and oxidative damage induced by amyloid-beta (Aβ) and increased the antioxidant enzyme activity in Alzheimer’s disease (AD) model C. elegans CL4176 through c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) signal pathway. Thus, CBP50-1 had a potential application in health industries.
- Subjects :
- Alzheimer’s disease
Cibotium barometz polysaccharide
Antioxidant
Aβ
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 18785352
- Volume :
- 16
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Arabian Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.48fb39f1cfb4426baa3fc3ffc39d1a33
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.arabjc.2023.104597