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A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus

Authors :
Peng Liu
Chaonan Shi
Shuang Liu
Jiajia Lei
Qisen Lu
Haichao Hu
Yan Ren
Ning Zhang
Congwei Sun
Lu Chen
Yaoyao Jiang
Lixiao Feng
Tianye Zhang
Kaili Zhong
Jiaqian Liu
Juan Zhang
Zhuo Zhang
Bingjian Sun
Jianping Chen
Yimiao Tang
Feng Chen
Jian Yang
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Abstract Wheat yellow mosaic virus (WYMV), a soil-borne pathogen, poses a serious threat to global wheat production. Here, we identify a WYMV resistance gene, TaRD21A, that belongs to the papain-like cysteine protease family. Through genetic manipulation of TaRD21A expression, we establish its positive role in the regulation of wheat to WYMV resistance. Furthermore, our investigation shows that the TaRD21A-mediated plant antiviral response relies on the release of a small peptide catalyzed by TaRD21A protease activity. To counteract wheat resistance, WYMV-encoded nuclear inclusion protease-a (NIa) suppress TaRD21A activity to promote virus infection. In resistant cultivars, a natural variant of TaRD21A features a alanine to serine substitution and this substitution enables the phosphorylation of Serine, thereby weakening the interaction between NIa and TaRD21A, reinforcing wheat resistance against WYMV. Our study not only unveils a WYMV resistance gene but also offers insights into the intricate mechanisms underpinning resistance against WYMV.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.48f3cc7f0aa9471aa06f54957c96082f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-43643-y