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KIM-1 and GADDI-153 gene expression in paracetamol-induced acute kidney injury: effects of N-acetylcysteine, N-acetylmethionine, and N-acetylglucosamine
- Source :
- Türk Biyokimya Dergisi, Vol 47, Iss 4, Pp 409-416 (2021)
- Publication Year :
- 2021
- Publisher :
- De Gruyter, 2021.
-
Abstract
- Acute kidney injury (AKI) is a critical clinical event characterized by a reduction in the excretory function of the kidneys. N-acetylcysteine (NAC), N-acetylmethionine (NAM) and N-acetylglucosamine (NAG) are antioxidants with scanty known genetic mechanisms. We aimed to assess both kidney injury molecule-1 (KIM-1) and growth-arrested DNA damage-inducible gene-153 (GADD-153) genes expression in paracetamol (PA) induced AKI. Also, to recognize whether NAC, NAM and/or NAG have roles in altering the expression of these genes for ameliorating the AKI induced by PA.
Details
- Language :
- English
- ISSN :
- 1303829X
- Volume :
- 47
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Türk Biyokimya Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.48d514001b3649b3a59f2224aee0f71e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/tjb-2021-0233