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Sex differences in hospitalized adult patients with cellulitis: A prospective, multicenter study

Authors :
Julio Collazos
Belén de la Fuente
Javier de la Fuente
Alicia García
Helena Gómez
María Rivas-Carmenado
Tomás Suárez-Zarracina
Enrique García-Carús
Silvia Suárez-Diaz
Héctor Enríquez
Paula Sánchez
María Alonso
Ian López-Cruz
Manuel Martín-Regidor
Ana Martínez-Alonso
José Guerra
Arturo Artero
Marino Blanes
Víctor Asensi
Source :
International Journal of Infectious Diseases, Vol 104, Iss , Pp 584-591 (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Objectives: Sex differences in adult cellulitis, a frequent cause of hospitalization, have not been analyzed. These differences were investigated in a large cellulitis series. Methods: This was a prospective observational study of 606 Spanish hospitalized cellulitis patients. Different comorbidities, clinical, diagnostic, and treatment data were compared between the sexes. Multiple logistic regression modeling was performed to determine the variables independently associated with sex. Results: Overall 606 adult cellulitis patients were enrolled; 314 (51.8%) were male and 292 (48.2%) were female. Females were older (mean age 68.8 vs 58.9 years, p < 0.0001), less likely to have prior wounds (p = 0.02), and more likely to have venous insufficiency (p = 0.0002) and edema/lymphedema (p = 0.0003) than males. The location of the infection differed between the sexes (p = 0.02). Males were more likely to have positive pus cultures (p = 0.0008), the causing agent identified (p = 0.04), and higher rates of Staphylococcus aureus infection (p = 0.04) and received longer antibiotic treatment (p = 0.03). Factors independently associated with female sex in the multivariate analysis were older age (p < 0.0001), prior cellulitis (p = 0.01), presence of edema/lymphedema as the predisposing factor (p = 0.004), negative versus positive pus culture (p = 0.0002), and location of cellulitis other than in the lower extremities (p = 0.035). Conclusions: Differences between male and female patients with cellulitis were age, recurrence, presence of edema/lymphedema, positivity of pus culture, and topography of the infection.

Details

Language :
English
ISSN :
12019712
Volume :
104
Issue :
584-591
Database :
Directory of Open Access Journals
Journal :
International Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.48c9f7dc689f482395948a4c44f37136
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ijid.2021.01.044