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Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis

Authors :
Yuya Ito
Takahiro Takazono
Yasushi Obase
Susumu Fukahori
Nobuyuki Ashizawa
Tatsuro Hirayama
Masato Tashiro
Kazuko Yamamoto
Yoshifumi Imamura
Naoki Hosogaya
Chizu Fukushima
Yoshitomo Morinaga
Katsunori Yanagihara
Koichi Izumikawa
Hiroshi Mukae
Source :
Journal of Fungi, Vol 8, Iss 5, p 436 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are important fungal infections caused by Aspergillus species. An overlap of ABPA and CPA has been reported; therefore, it is critical to determine whether the main pathology is ABPA or CPA and whether antifungals are required. In this study, we investigated whether the serum cytokine profile is useful for understanding the pathology and for differentiating between these diseases. We compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA at Nagasaki University Hospital between January 2003 and December 2018. In total, 14 healthy subjects, 19 patients with asthma, 11 with ABPA, and 10 with CPA were enrolled. Interleukin (IL) -5 levels were significantly higher in patients with ABPA than in those with CPA, and IL-33 and tumor necrosis factor (TNF) levels were significantly higher in patients with CPA than in those with asthma (p < 0.05, Dunn’s multiple comparison test). The sensitivity and specificity of the IL-10/IL-5 ratio (cutoff index 2.47) for diagnosing CPA were 70% and 100%, respectively. The serum cytokine profile is useful in understanding the pathology of ABPA and CPA, and the IL-10/IL-5 ratio may be a novel supplemental biomarker for indicating the pathology of CPA.

Details

Language :
English
ISSN :
2309608X
Volume :
8
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
edsdoj.48c831fa429a4eada55ad6742c0b89d5
Document Type :
article
Full Text :
https://doi.org/10.3390/jof8050436