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Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis

Authors :
Toshihide Izumida
Teruhiko Imamura
Makiko Nakamura
Koichiro Kinugawa
Source :
Journal of Cardiovascular Development and Disease, Vol 8, Iss 12, p 182 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern.

Details

Language :
English
ISSN :
23083425
Volume :
8
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Journal of Cardiovascular Development and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.486d5d3bca949758dc22eb142c729bb
Document Type :
article
Full Text :
https://doi.org/10.3390/jcdd8120182