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ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations in AML patients
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4858a0bedd1541a2a819f03ad5087413
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms15429