Back to Search Start Over

Metabolomic Profile of Abdominal Aortic Aneurysm

Authors :
Jüri Lieberg
Anders Wanhainen
Aigar Ottas
Mare Vähi
Mihkel Zilmer
Ursel Soomets
Martin Björck
Jaak Kals
Source :
Metabolites, Vol 11, Iss 8, p 555 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Abdominal aortic aneurysm (AAA) is characterized by structural deterioration of the aortic wall, leading to aortic dilation and rupture. The aim was to compare 183 low molecular weight metabolites in AAA patients and aorta-healthy controls and to explore if low molecular weight metabolites are linked to AAA growth. Blood samples were collected from male AAA patients with fast (mean 3.3 mm/year; range 1.3–9.4 mm/year; n = 39) and slow growth (0.2 mm/year; range −2.6–1.1 mm/year; n = 40), and from controls with non-aneurysmal aortas (n = 79). Targeted analysis of 183 metabolites in plasma was performed with AbsoluteIDQ p180 kit. The samples were measured on a QTRAP 4500 coupled to an Agilent 1260 series HPLC. The levels of only four amino acids (histidine, asparagine, leucine, isoleucine) and four phosphatidylcholines (PC.ae.C34.3, PC.aa.C34.2, PC.ae.C38.0, lysoPC.a.C18.2) were found to be significantly lower (p < 0.05) after adjustment for confounders among the AAA patients compared with the controls. There were no differences in the metabolites distinguishing the AAA patients with slow or fast growth from the controls, or distinguishing the patients with slow growth from those with fast growth. The current study describes novel significant alterations in amino acids and phosphatidylcholines metabolism associated with AAA occurrence, but no associations were found with AAA growth rate.

Details

Language :
English
ISSN :
22181989
Volume :
11
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Metabolites
Publication Type :
Academic Journal
Accession number :
edsdoj.482b96533f064a138b75de449f2361b2
Document Type :
article
Full Text :
https://doi.org/10.3390/metabo11080555