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354 Unitary neural correlates of executive control in pediatric transdiagnostic psychopathology
- Source :
- Journal of Clinical and Translational Science, Vol 7, Pp 104-105 (2023)
- Publication Year :
- 2023
- Publisher :
- Cambridge University Press, 2023.
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Abstract
- OBJECTIVES/GOALS: Childhood psychiatric symptoms are highly comorbid. Their co-occurrence and association with negative life outcomes is partially explained by deficits in executive control, or processes enabling self-regulation. Here, we test a novel executive neural target in three fMRI tasks and its relevance to shared psychopathology. METHODS/STUDY POPULATION: We studied 60 children [15 F/45 M; mean age (SD)=11.6 years (1.62)] with diverse diagnoses including attention deficit disorder (n=26) and autism spectrum disorder (n=22). We extracted a latent general factor of psychopathology using principal component analyses applied to parent-report Child Behavior Checklist syndrome scores. Subjects completed 3 executive control fMRI probes, tapping adaptive control, working memory, and inhibition. Correlational psychophysiological interaction (cPPI) analysis measured correlations between executive control-related modulations of activity in 414 network-affiliated parcels. We selected parcels exhibiting control-related cross-network correlations as well as control-related activity across all tasks and tested them for association with psychopathology. RESULTS/ANTICIPATED RESULTS: cPPI connectivity matrices were thresholded and graphs were identified using the Network-Based Statistic toolbox (p90th percentile PC) as well as control-related activation (>10% activated voxels; p DISCUSSION/SIGNIFICANCE: Our results examine cross-network interactions between brain regions during 3 fMRI tasks and their role in explaining individual variation in psychopathology. As executive control links to both comorbidity and life outcomes, identifying the clinically-relevant neural correlates of controlled behavior may lead to transdiagnostic treatments.
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20598661
- Volume :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Clinical and Translational Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.47f09c724d445bb8dcdc92f05db9072
- Document Type :
- article
- Full Text :
- https://doi.org/10.1017/cts.2023.394