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ALLOGENEIC BONE GRAFTING MATERIALS – UPDATE OF THE CURRENT SCIENTIFIC STATUS

Authors :
R. Schnettler
J. Franke
D. Rimashevskiy
N. Zagorodniy
N. Batpenov
R. E. Unger
S. Wenisch
M. Barbeck
Source :
Travmatologiâ i Ortopediâ Rossii, Vol 23, Iss 4, Pp 92-100 (2017)
Publication Year :
2017
Publisher :
Vreden Russian Research Institute of Traumatology and Orthopedics, 2017.

Abstract

Worldwide population aging and associated with it epidemics of osteoporosis, widespread of bone and joint reconstructive surgery and first of all joint replacement lead to explosive growth of interest in bone grafting.Although autografts are still the golden standard in bone regeneration, allogeneic bone substitutes have reached a state that allows for their application with satisfying clinical results. However, it has repeatedly been supposed that the different allogeneic materials underwent different purification processes, which modifies bone regeneration properties of these materials and also for different safety conditions. In the present publication, the treatment of the precursor tissue, the safety conditions, and the regenerative possibilities of C+TBA bone blocks based in preclinical and clinical data are described. Thus, it is described how the risks of infections and also immunological reactions becomes completely eliminated, while the special purification process allows for preservation of the native structure of the bone block. Both the in vitro studies and the clinical trials including histological follow-ups showed the optimal regeneration properties of these bone blocks. It has been shown that the allogeneic bone grafts have been integrated without causing inflammatory anomalies at the implantation site. Altogether, the allogeneic bone substitute material serves as an excellent basis for the formation of new bone. Finally, the combination of the allogeneic C+TBA bone blocks with different antibiotics is described. Interestingly, it is possible to combine the allogeneic bone substitute ether with antibiotics in the sense of prophylaxis and/or with bone marrow aspirate in order to accelerate bone remodeling.

Details

Language :
Russian
ISSN :
23112905 and 25420933
Volume :
23
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Travmatologiâ i Ortopediâ Rossii
Publication Type :
Academic Journal
Accession number :
edsdoj.47ba45554d1a48fa8bcdb89a11ce78e1
Document Type :
article
Full Text :
https://doi.org/10.21823/2311-2905-2017-23-4-92-100