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Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

Authors :
Herbert Schulz
Ann-Kathrin Ruppert
Stefan Herms
Christiane Wolf
Nazanin Mirza-Schreiber
Oliver Stegle
Darina Czamara
Andreas J. Forstner
Sugirthan Sivalingam
Susanne Schoch
Susanne Moebus
Benno Pütz
Axel Hillmer
Nadine Fricker
Hartmut Vatter
Bertram Müller-Myhsok
Markus M. Nöthen
Albert J. Becker
Per Hoffmann
Thomas Sander
Sven Cichon
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorders.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4760a9c2746b4a878c2dfd7b18475253
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01818-4