THE COMPARATIVE ANALYSIS OF THE EFFECT OF FLUOROQUINOLONES ON CHICK BLOOD LEUKOGRAM

Background: The goal of our study is the comparative analysis of the effect of fluoroquinolones on the chicken leukogram. Materials and methods: In the study we used Ciprofloxacin, Ofloxacin, Levofloxacin, Moxifloxacin, Norfloxacin, Enrofloxacin. For the study we made seven groups, thirty-five chickens in each group. The control set was given pure drinking water throughout the experiment; each of the experimental groups was given water with one of the above-mentioned antibacterial fluoroquinolone drugs, the dosage being 200 mg per liter. The blood samples were collected with cardiac punctures on the first, third, fifth, seventh and ninth days after the withdrawal of the drug. The leukogram contains the total number of leucocytes and the content of separate cell types and their total numbers. Results: The valid changes in the number of pseudoeosinophils do not show clear tendencies, such changes are observed once under the influence of each drug on different days of the research. On the seventh and the ninth days after the drug withdrawal all the fluoroquinolones except Ofloxacin caused lymphopenia. Ciprofloxacin is the only tested drug, the usage of which does not cause valid changes in the number of monocytes. Those groups that receive Enrofloxacin or Ofloxacin have a short period of eosinophilia. Levofloxacin, Enrofloxacin, Ofloxacin cause refractory basophilia. Conclusion: The application of antimicrobial fluoroquinolone drugs in the course of ten days results in changes in the ratio of different kinds of leucocytes in chicken blood, but at the conclusion of the experiment every value in the leukogram returns to physiological standard.